# Disconnectome morphospace

Figure: Uniform Manifold Approximation and Projection (UMAP) [1] embedding of N=1333 stroke lesions [2].

Brain lobe annotations indicate the dominant location of each stroke lesion. R=right hemisphere; L=left hemisphere.

The disconnectome morphospace shown in the Figure above summarizes the UMAP (Uniform Manifold Approximation and Projection) importation of single patients in a common 2-dimensional space. The UMAP coordinates will be used to inform the neuropsychological scores prediction model [3].

**References**

1. McInnes, L., J. Healy, and J. Melville, UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction. arXiv, 2018. 1802.03426v2

2. Xu, T., et al., High-dimensional therapeutic inference in the focally damaged human brain. Brain, 2018. 141(1): p. 48-54.

3. Talozzi, L., et al. Latent disconnectome prediction of long-term cognitive symptoms in stroke. Research Square, doi:10.21203/rs.3.rs-1181593/v1 (2022).